TB05/10 × 5mg/COA ×4
HEA / Healing & Recovery
TB-500 (5mg) – TB05
$445.50
per box of 10 vials, 5mg per vial
Box of 10 vials
- Code
- TB05
- Box
- 10 vials
- Per vial
- 5mg
- Form
- Lyophilised powder
- Reports held
- Purity, Sterility, Heavy metals, Endotoxin
- Availability
- In stock
Supplied strictly for laboratory research. Not for human or veterinary consumption, and not for diagnostic or therapeutic use. Handling is the purchaser's responsibility.
Laboratory reports
Reports on file for this batch
About the compound
TB-500 (5mg) — Research Peptide
TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein expressed ubiquitously across mammalian cell types. Unlike the full Tβ4 protein, the TB-500 fragment retains the primary actin-binding domain responsible for Tβ4’s documented biological activities, making it the standard research form used in published studies investigating Thymosin Beta-4 biology.
Biology of Thymosin Beta-4
Thymosin Beta-4 was first isolated from thymic tissue in the 1960s and initially characterised as a thymic hormone. Subsequent research established it as a ubiquitous intracellular protein whose primary function is G-actin sequestration — binding to monomeric actin and preventing its polymerisation into F-actin filaments. This regulatory role in actin dynamics has far-reaching consequences for cell motility, as directed cell migration depends on controlled actin polymerisation at the leading edge of migrating cells.
Research Applications
Published research has investigated TB-500/Tβ4 across several biological contexts:
- Wound healing: Tβ4 promotes dermal fibroblast migration and wound closure via ILK (integrin-linked kinase) activation. Goldstein et al. demonstrated accelerated wound repair in rodent models with Tβ4 administration.
- Cardiac research: A landmark 2004 Nature study (Bock-Marquette et al.) demonstrated Tβ4 activates epicardial progenitor cells and promotes cardiomyocyte survival following myocardial injury models — a finding that generated significant follow-on cardiac regeneration research.
- Skeletal muscle: Tβ4 promotes satellite cell differentiation and muscle fibre regeneration following injury in rodent models.
- Corneal and ocular: Phase 2 clinical trials investigated Tβ4 in dry eye and neurotrophic keratopathy — among the few peptides with human clinical data in this domain.
Product Specifications
- Peptide: TB-500 (Thymosin Beta-4 active fragment)
- Dose: 5mg per vial
- Format: Lyophilised powder, bulk box of 10 vials
- Purity: ≥98% verified by Janoshik HPLC analysis
- Testing: Purity, sterility, endotoxin, heavy metals — COA available
- Storage: -20°C lyophilised. Stable 24 months.
For laboratory research use only. Not for human therapeutic use.
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